Energy

FOXO4-DRI.

Available Variants

10 mg

View lab reports Quality process

Research area: Energy

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For research purposes only. Not intended for use in humans or animals.

Longevity & energy metabolism research

About FOXO4-DRI

FOXO4-DRI is studied in research on cellular energy metabolism and longevity. In senescent cells, the transcription factor FOXO4 sequesters p53, blocking its apoptotic function. FOXO4-DRI competes with endogenous FOXO4 for p53 binding, releasing p53 and selectively triggering apoptosis in senescent cells while largely sparing healthy cells.

Research Application

A key candidate in senescence and aging research: in the original study, FOXO4-DRI improved fitness, fur density, and kidney function in aged mice, and accelerated recovery from chemotherapy.

Important to know

Claims circulating online are often not backed by valid clinical data. Treat all information as a starting point for your own scientific research, not as usage guidance.

Content 10 mg

Form Lyophilized powder

Category Energy

Purity & Identity see lab reports →

Sequence / Structure D-retro-inverso (DRI) peptide derived from the FOXO4 forkhead domain, designed to block the FOXO4–p53 interaction.

Regulatory Status Research-only peptide, no approval; efficacy demonstrated only in cell-culture and mouse models to date — no registered or published human trials.

Sequence and regulatory status data are based on publicly available sources and refer to the compound in general, not to a specific product.

Research Overview

Research on longevity and energy metabolism is primarily supported by preclinical data.

Baar MP, et al. Cell. 2017;169(1):132–147.e16. PMID 28340339

References without a PMID can be located via the respective publisher. This overview does not claim to be exhaustive.

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