Energy

AICAR.

Available Variants

50 mg 100 mg

View lab reports Quality process

Research area: Energy

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For research purposes only. Not intended for use in humans or animals.

Longevity & energy metabolism research

About AICAR

AICAR is studied in research on cellular energy metabolism and longevity. AICAR is phosphorylated intracellularly to ZMP, an AMP mimetic that allosterically activates AMP-activated protein kinase (AMPK). Activated AMPK promotes mitochondrial biogenesis and oxidative-metabolism genes in skeletal muscle.

Research Application

Known as an 'exercise mimetic': in a widely cited study, AICAR increased running endurance by 44% in sedentary mice without training. Prohibited in competitive sport due to its performance-enhancing potential.

Important to know

Claims circulating online are often not backed by valid clinical data. Treat all information as a starting point for your own scientific research, not as usage guidance.

Content 50 mg, 100 mg

Form Lyophilized powder

Category Energy

Purity & Identity see lab reports →

Sequence / Structure Not a peptide — a nucleoside analog (5-aminoimidazole-4-carboxamide ribonucleotide / acadesine), a naturally occurring AMPK-activating intermediate of purine metabolism.

Regulatory Status Research compound, historically also investigated as a drug (acadesine) in cardiology trials; prohibited as a doping agent by WADA since 2009.

Sequence and regulatory status data are based on publicly available sources and refer to the compound in general, not to a specific product.

Research Overview

Research on longevity and energy metabolism is primarily supported by preclinical data.

Narkar VA, et al. Cell. 2008;134(3):405–415. PMID 18674809

References without a PMID can be located via the respective publisher. This overview does not claim to be exhaustive.

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