MOTS-c.
About MOTS-c
MOTS-c is studied in research on cellular energy metabolism and longevity. MOTS-c is one of the few known peptides encoded directly by the mitochondrial rather than the nuclear genome. Cell models describe activation of AMPK, the cellular energy sensor.
Research Application
Studied in metabolism and longevity research in connection with AMPK activation and mitochondrial signaling — notable as one of the few known peptides encoded directly by the mitochondrial rather than the nuclear genome.
Important to know
Claims circulating online are often not backed by valid clinical data. Treat all information as a starting point for your own scientific research, not as usage guidance.
Sequence and regulatory status data are based on publicly available sources and refer to the compound in general, not to a specific product.
Research Overview
Research on longevity and energy metabolism is primarily supported by preclinical data.
- Lee C, et al. Cell Metabolism. 2015;21(3):443–454.
- Kim KH, et al. Cell Metabolism. 2018;28(3):516–524. PMID 29983246
- Reynolds JC, et al. Nature Communications. 2021;12(1):470.
- Gudiksen A, et al. Free Radic Biol Med. 2026;246:682–696.
References without a PMID can be located via the respective publisher. This overview does not claim to be exhaustive.
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