Melanotan I.
About Melanotan I
Melanotan I is studied in dermatological and anti-aging research, e.g. in relation to skin and pigmentation models. Unlike non-selective melanocortin agonists, MT-1 primarily activates the MC1 receptor on melanocytes, stimulating melanin production without meaningful effects on appetite- or sexual-function receptors.
Research Application
Studied in pigmentation research, including in connection with photoprotection in photodermatological conditions. The closely related, MC1-selective formulation afamelanotide is the only FDA-approved melanocortin peptide in this group (erythropoietic protoporphyria).
Important to know
Claims circulating online are often not backed by valid clinical data. Treat all information as a starting point for your own scientific research, not as usage guidance.
Sequence and regulatory status data are based on publicly available sources and refer to the compound in general, not to a specific product.
Research Overview
The evidence base for skin and pigmentation peptides is largely based on preclinical and early clinical investigations.
- Barnetson RS, et al. Arch Dermatol. 2004;140(7):827–835. PMID 15262693
- Langendonk JG, et al. NEJM. 2015;373(1):48–59. PMID 26132941
- Biolcati G, et al. Br J Dermatol. 2015;172(6):1601–1612. PMID 25494545
References without a PMID can be located via the respective publisher. This overview does not claim to be exhaustive.
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