Growth

ACE-031.

Available Variants

1 mg

View lab reports Quality process

Research area: Growth

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For research purposes only. Not intended for use in humans or animals.

GH-axis research

About ACE-031

ACE-031 is among the peptides researched in the context of the growth hormone (GH) axis. Acts as a decoy receptor that binds and sequesters myostatin and related TGF-beta superfamily ligands, preventing them from binding native ActRIIB on muscle cells — blocking myostatin's growth-inhibitory signaling.

Research Application

Historically studied as a myostatin-pathway inhibitor for muscle-wasting conditions; today referenced mainly as a cautionary case study in off-target toxicity from cross-reactivity with related BMP ligands.

Important to know

Claims circulating online are often not backed by valid clinical data. Treat all information as a starting point for your own scientific research, not as usage guidance.

Content 1 mg

Form Lyophilized powder

Category Growth

Purity & Identity see lab reports →

Sequence / Structure Not a small peptide but a fusion protein (ramatercept): the extracellular ligand-binding domain of activin receptor type IIB fused to a human IgG1 Fc domain — a soluble decoy receptor.

Regulatory Status Developed by Acceleron Pharma; tested in a Phase 2 trial in boys with Duchenne muscular dystrophy. The trial was halted in 2011 after safety signals (epistaxis, telangiectasia). Acceleron and Shire discontinued the program in 2013; never approved for any indication.

Sequence and regulatory status data are based on publicly available sources and refer to the compound in general, not to a specific product.

Research Overview

Numerous preclinical and some clinical studies exist on the GH axis, with evidentiary strength varying by substance.

Campbell C, et al. Muscle Nerve. 2017;55(4):458–464. PMID 27462804

References without a PMID can be located via the respective publisher. This overview does not claim to be exhaustive.

Similar Peptides

Growth IGF-1 LR3 View → Growth MGF View → Growth HGH View →

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